Filtered By:
Cancer: Leukemia

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 28081 results found since Jan 2013.

Cellular Therapies for the Treatment of Hematological Malignancies; Swine Are an Ideal Preclinical Model
The absence of clinically relevant large animal tumor models has historically forced experimental cellular therapies for hematological malignancies to translate directly from murine models to clinical trials. However, recent advances highlight swine as an ideal large animal model to demonstrate the safety of murine proof of concept studies prior to their implementation clinically. The availability of the MHC defined MGH miniature swine herd has been key for the development of novel approaches for hematopoietic cell and solid organ transplantation. New spontaneously arising hematological malignancies in these swine, specifi...
Source: Frontiers in Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research

Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway
In conclusion, our findings suggest that Cd induces intestinal apoptosis and autophagy in swine by inactivating the PI3K/Akt signaling pathway.PMID:35091949 | DOI:10.1007/s11356-022-18863-2
Source: Cell Research - January 29, 2022 Category: Cytology Authors: Haoran Zhang Jiaqiang Huang Jie Yang Jingzeng Cai Qi Liu Xintong Zhang Jun Bao Ziwei Zhang Source Type: research

Viruses, Vol. 7, Pages 4978-4996: Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection
Viral interactions with host nucleus have been thoroughly studied, clarifying molecular mechanisms and providing new antiviral targets. Considering that African swine fever virus (ASFV) intranuclear phase of infection is poorly understood, viral interplay with subnuclear domains and chromatin architecture were addressed. Nuclear speckles, Cajal bodies, and promyelocytic leukaemia nuclear bodies (PML-NBs) were evaluated by immunofluorescence microscopy and Western blot. Further, efficient PML protein knockdown by shRNA lentiviral transduction was used to determine PML-NBs relevance during infection. Nuclear distribution of ...
Source: Viruses - September 15, 2015 Category: Virology Authors: Margarida SimõesJosé RinoInês PinheiroCarlos MartinsFernando Ferreira Tags: Article Source Type: research

Donor Leukocyte Infusion Mediated Graft-Versus-Host Responses in a Pre-Clinical Swine Model of Haploidentical Hematopoietic Cell Transplantation
The donor-anti-host cellular reactivity associated with allogeneic hematopoietic cell transplantation (HCT) is a powerful anti-leukemia treatment. However, graft-versus-host disease (GVHD) continues to limit HCT, especially across major histocompatibility (MHC) barriers. We previously described successful hematopoietic stem cell engraftment in MHC-mismatched swine without GVHD using novel reduced intensity conditioning (RIC) regimens consisting of partial, transient recipient T-cell depletion (with or without thymic or low-dose total body irradiation), and a short course of cyclosporine A (CyA).
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Raimon Duran-Struuck, Abraham J. Matar, Rebecca L. Crepeau, Vimukthi Pathiraja, Thomas R. Spitzer, Roderick T. Bronson, David H. Sachs, Christene A. Huang Tags: Allogeneic Transplants Source Type: research

Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster
& M Greaves
Source: Leukemia - May 19, 2017 Category: Hematology Authors: G Cazzaniga L Bisanti G Randi S Deandrea S Bungaro F Pregliasco D Perotti F Spreafico G Masera M G Valsecchi A Biondi M Greaves Source Type: research

Relationship Between State-Level Google Online Search Volume and Cancer Incidence in the United States: Retrospective Study
Conclusions: Cancer incidence is correlated with online search volume at the state level. Search patterns were temporally associated with cancer awareness months and celebrity announcements. Online searches reflect public awareness. Advancing understanding of online search patterns could augment traditional epidemiologic surveillance, provide opportunities for targeted patient engagement, and allow public information campaigns to be evaluated in ways previously unable to be measured.
Source: Journal of Medical Internet Research - January 8, 2018 Category: General Medicine Authors: Charles A. Phillips Allison Barz Leahy Yimei Li Marilyn M. Schapira L. Charles Bailey Raina M. Merchant Source Type: research

Is a Matched Unrelated Donor Search Needed for All Allogeneic Transplant Candidates?
ConclusionsRace, haplotype frequency and disease status at the time of MUD search influence probability to identify a MUD and receive a transplant. Patients with low likelihood to receive a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.DisclosuresKonopleva: Stemline Therapeutics: Research Funding. Oran: AROG pharmaceuticals: Research Funding; Celgene: Consultancy, Research Funding; ASTEX: Research Funding. Champlin: Otsuka: Research Funding; Sanofi: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ciurea, S. O., Borges Bittencourt, M. C., Milton, D. R., Cao, K., Kongtim, P., Rondon, G., Chen, J., Konopleva, M. Y., Ramos Perez, J. M., Elshazly, M., Aljadayeh, M., Alvarez, M., Im, J. S., Alatrash, G., Mehta, R. S., Popat, U., Bashir, Q., Oran, B., Ho Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research

The search for cis-regulatory driver mutations in cancer genomes.
Authors: Poulos RC, Sloane MA, Hesson LB, Wong JW Abstract With the advent of high-throughput and relatively inexpensive whole-genome sequencing technology, the focus of cancer research has begun to shift toward analyses of somatic mutations in non-coding cis-regulatory elements of the cancer genome. Cis-regulatory elements play an important role in gene regulation, with mutations in these elements potentially resulting in changes to the expression of linked genes. The recent discoveries of recurrent TERT promoter mutations in melanoma, and recurrent mutations that create a super-enhancer regulating TAL1 expression...
Source: Oncotarget - September 13, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Proteomics Versus Clinical Data and Stochastic Local Search Based Feature Selection for Acute Myeloid Leukemia Patients ’ Classification
This study proposes a meta-heuristic framework using stochastic local search (SLS) combined with random forest (RF) where the aim is to specify the most important genes and proteins leading to the best classification of Acute Myeloid Leukemia (AML) patients. First we use a stochastic local search meta-heuristic as a feature selection technique to select the most significant proteins to be used in the classification task step. Then we apply RF to classify new patients into their corresponding classes. The evaluation technique is to run the RF classifier on the training data to get a model. Then, we apply this model on the t...
Source: Journal of Medical Systems - June 4, 2018 Category: Information Technology Source Type: research

ATP-Binding Cassette transporters' gene expression in pediatric patients with acute leukemia; a comprehensive analysis of published reports through PubMed search engine.
Authors: Mehrvar N, Akbari ME, Rezvany MR, Abolghasemi H, Saberynejad J, Mehrvar A, Faranoush M, Keramatinia AA, Shekarriz-Foumani R, Movafagh A Abstract Multidrug resistance based on ABC transporters' gene expression is one of the most important health challenges through chemotherapy of patients. This resistance can cause relapse or treatment failure. The goal of this conducted study was to evaluate the results of published reports which considered ABC transporters' gene expression in pediatric patients with acute leukemia. PubMed as a free search engine was chosen. The following Mesh terms were used as: "ATP-bind...
Source: Cellular and Molecular Biology - March 13, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

A Case of Acute Leukemia Following Remission of COVID-19 Infection; an Urge to Search for a Probable Association
Arch Acad Emerg Med. 2021 Jul 24;9(1):e51. eCollection 2021.ABSTRACTMany aspects of Covid-19 infection, especially its complications and long-term health consequences are still unknown. Several reports concerning concomitant covid-19 infection and hematological disorders have been published recently. We aim to present a unique case of acute myeloid leukemia in a 61-year-old man with a previous history of covid-19 infection 40 days ago, with near complete resolution of signs and symptoms attributable to covid-19 infection. After 3 weeks, the patient presented again with progressive weakness, nausea, vomiting, and epigastric...
Source: Accident and Emergency Nursing - August 18, 2021 Category: Emergency Medicine Authors: Seyyed Mojtaba Nekooghadam Afshin Moradi Kimia Karimi Toudeshki Mehdi Pishgahi Source Type: research